- Became a father for the 1st time at age 30 when his wife Lara Wechsler gave birth to their daughter Alma Higuaín on May 21, 2018.
- Son of footballer Jorge Higuaín and Nancy Zacarías.
- Younger brother of footballer Federico Higuaín.
- Striker for River Plate (2005-06), Real Madrid (2007-2013), S.S.C. Napoli (2013-2016) Juventus F.C. (2016-2018, 2019-20), A.C. Milan (2018) and Chelsea F.C. (2019) and Inter Miami C.F. (2020-).
- Was named in the South America Team of the Year in 2006.
- Honours with Real Madrid: La Liga (2007, 2008, 2012), Spanish Super Cup (2008, 2012) and Spanish Cup (2011). Honours with S.S.C. Napoli: Italian Cup (2014) and Italian Super Cup (2014). Honours with Juventus F.C.: Serie A (2017) and Italian Cup (2017).
- Was romantically involved with Micaela Vázquez, Soledad Fandiño, Ailén Bechara, Zaira Nara, Noelia Marzol and Manuela Ferrera.
- (May 23, 2013) He scored 100 goals in Spanish League.
- Was in an on-off relationship with Daniela Saurwald (2011-2016).
- Member of the Argentina National team who finished runner-up at the FIFA World Cup (2014), Copa América (2015) and Copa América Centenario (2016).
- (October 28, 2017) He scored 100 goals in Italian League.
- Named in the Serie A Team of the Year in 2014, 2016 and 2017.
- Named in the UEFA Europa League Squad of the season in 2014 and 2015.
- Top scorer of the Serie A (2016).
- Named in the ESM Team of the Year in 2016.
- 75 appearances for Argentina National Football Team (2009-2018); scored 31 goals. Member of the Copa América 2011, 2015, 2016, and the South Africa '10, Brazil '14 and Russia '18 squads.
- Played well over 250 games for Real Madrid.
- Played well over 100 games for S.S.C. Napoli and Juventus F.C..
- He is the #5 Argentine's most scorer in Europe. The others are Lionel Messi, Delio Onnis, Sergio Agüero and Alfredo Di Stéfano.
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