- Personally financed the 2003 California recall election that removed Gray Davis from the governor's office. As a result of the recall election, actor Arnold Schwarzenegger became the state's new governor.
- Republican U.S. Representative from California (2001-2019, 2021-), currently representing most of San Diego County; from 2001-2019, his district was situated in the county's northwest.
- Chairman, U.S. House Oversight and Government Reform Committee (2011-2015).
- Named "Entrepreneur of the Year" in 1995.
- Member, U.S. House Judiciary Committee (? - present), U.S. House Foreign Affairs Committee (? - present).
- Favorite songs: "Cat's in the Cradle" by Harry Chapin, "American Pie" by Don McLean, "Take It Easy" and "Life in the Fast Lane" by Eagles, "Wouldn't It Be Nice" by The Beach Boys, "Bad, Bad Leroy Brown" by Jim Croce, "Bridge Over Troubled Water" by Simon & Garfunkel, "You're So Vain" by Carly Simon.
- Father of son, William Issa.
- The district Issa represents was the 48th District during his first term (2001 - 2003) and was reconfigured as the 49th District from 2003-2019, then the 50th from 2021-2023 before becoming the 48th District again in 2023.
- Issa founded and ran Directed Electronics, Inc., and it is his voice which is famously heard "Please step away from the car", as the warning for DEI's lead product, the Viper car alarm. Directed Electronics diversified, becoming, as of 2004, North America's largest after market automotive electronics manufacturer. Issa divested his interest in Directed Electronics when he was elected to Congress.
- Issa is a self-made millionaire, and his net worth has been estimated to be as high as $450 million. Since coming to office in January 2001, Issa has been estimated to be the wealthiest or one of the top five wealthiest members of Congress almost every year since coming to office.
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