Clow is best known for co-creating - along with Steve Hayden, the Apple 1984 commercial which launched the Apple Macintosh and the "Think Different " slogan. The 60-second TV spot was made for a budget of $900,000 and is considered a masterpiece in advertising.
He is also known for his work on the PlayStation, Energizer Bunny and Taco Bell chihuahua campaigns. He is a member of numerous advertising and creative halls of fame.