- Began his baseball career as a catcher, then moved to second base, and now plays in the outfield
- Has spent his entire career with the Houston Astros
- Although he throws and bats right-handed, he writes left-handed.
- Is considered one of the greatest defensive players in MLB history winning 4 Rawlings Gold Glove awards at 2nd base.
- Is considered the greatest Houston Astro of all-time.
- He is the only player in MLB history to be an all-star catcher and and a 2nd baseman.
- His best season was in 1998 when he hit .325 with 20 HR, 88 RBI, 51 doubles, 123 runs, and 210 hits. He ranked 5th in 1998 for NL MVP.
- He has played in 7 all-star games thus far. He ranks (as of the end of the 2004 season) 65th all time for career games played (4th among all active players), 48th all time in at bats (2nd among all active players), 40th all time in runs (3rd among all active players), 67th all time in career hits (4th among all active players), 66th all time in total bases (9th among all acvtive players), 18th all time in doubles (2nd among all active players), 67th all time in career stolen bases (6th among all active players), 59th all time in extra base hits (10th among all active players), 38th all time in career times on base (3rd among all active players),and 4th all time in career hit by pitches (1st among all active players)
- On 29 June 2005, he was hit by a pitch for for the 268th time in his career, breaking the record held for many years by Don Baylor.
- Made major league debut on 26 June 1988.
- Graduated from Kings Park High School on Long Island where both his football and baseball number are retired.
- Has three children: sons Conor Joseph Biggio (b. January 7, 1993) and Cavan Thomas Biggio (b. April 11, 1995) daughter Quinn Patricia Biggio (b. September 27, 1999)
- Given the 2007 Roberto Clemente Award in Denver, Colorado on October 27, 2007 for his humanitarian causes. First Astro to win the award.
- National spokesman for the Sunshine Kids Foundation, for children with cancer.
- First Houston Astros to reach 3,000 hits and the 27th player [June 28, 2007].
- Good friend of fellow Houston Astros Jeff Bagwell and Ken Caminiti.
- Is now a coach at Houston's St. Thomas High School.
- (November 12) Officially retired. Biggio said he would retire at the end of the regular season. (2007)
- He was nominated for the 2014 New Jersey Hall of Fame in the Sports Category.
- Inducted into the National Baseball Hall of Fame in 2015.
- He was nominated for the 2019-2020 Class of New Jersey Hall of Fame in the Sports category.
- He was nominated for the 2021 New Jersey Hall of Fame in the Sports category.
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