- Was inspired by his late father, a contractor, not to work in manual labor. Mackie's father later died in New Orleans due to Hurricane Katrina.
- He was roommates with Lee Pace at Juilliard.
- He opened a bar called NoBar in Brooklyn, New York in the summer of 2011.
- Married his longtime girlfriend, Sheletta Chapital, in December 2014. They have four children together.
- A graduate of The Juilliard School (Group 30).
- He enjoys skydiving and has done it six times.
- He appeared in two Best Picture Academy Award winners: Million Dollar Baby (2004) and The Hurt Locker (2008).
- His brother is an engineer in New Orleans, Louisiana who appeared in Spike Lee's documentary on Hurricane Katrina, When the Levees Broke: A Requiem in Four Acts (2006).
- Planned to be an engineer before falling in love with acting.
- His character in 8 Mile (2002) at one point has his rapping skills compared negatively to those of Tupac Shakur. 6 years later, Anthony played Tupac in Notorious (2009).
- Is currently (as of 2010) seeking a producer for a script he has about Olympic athlete Jesse Owens.
- Friends with Chadwick Boseman.
- Graduated high school from North Carolina School of the Arts with a concentration in acting.
- Attended New Orleans School for Creative Arts.
- Attended North Carolina School of the Arts, mid-90s.
- A featured player in Regina Taylor's play, Drowning Crow, at the Manhattan Theatre Club. (January 2004)
- Performing Martin McDonagh's "A Behanding in Spokane" at the Schoenfeld Theatre on Broadway. (March 2010)
- He has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: The Hurt Locker (2008).
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