- Despite playing fairly sinister characters, he was described by Simon Pegg in the Spaced (1999) Series 1 DVD commentary as "the sweetest man alive".
- His father's family was Belarusian and Polish. His mother's family was of British descent.
- Had an uncredited role as one of the "Shrunken Heads" at the entrance to the "Three Broomsticks" pub in Hogsmeade in Harry Potter and the Prisoner of Azkaban (2004).
- Provided lines for the Battle Droid Commander in Star Wars: Episode I - The Phantom Menace (1999) who asked for Qui-Gon Jinn's identification and the Gungan Scout with the large binoculars who says 'They's a-coming!'.
- Has actually performed as 3 Darths, as Darth Maul in Star Wars: Episode I - The Phantom Menace (1999), as Darth Chef in South Park (1997), and as a parody of Darth Vader on The Peter Serafinowicz Show (2007).
- Has a son named Sam with actress and wife, Sarah Alexander. He was born in March 2007.
- Brother of James Serafinowicz and Helen Serafinowicz.
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