- His daughter Charlotte is the baby saying "Bye bye" over his production company's name (Doozer) at the end of Scrubs (2001).
- Has said in interviews that he is a huge The Simpsons (1989) fan and intends Scrubs (2001) to be the way The Simpsons (1989) would if it were a live-action show set in a hospital, in terms of the humor, large recurring cast and numerous guest stars. A 2006 episode even borrowed a joke from The Simpsons (1989) when J.D. said of Grey's Anatomy (2005): "That show is so realistic, it's like someone was watching our lives and put it on television!" "Lisa Simpson" made a similar comment about the Jim Henson series Dinosaurs (1991).
- Bill and his wife, Christa Miller, became the parents of their third child, Henry Vanduzer Lawrence, on October 8, 2006 in Los Angeles.
- Son, William Stoddard Lawrence, was born on January 3, 2003.
- Majored in English at the College of William and Mary in Williamsburg, Virginia. He graduated in 1990.
- Attended The College of William and Mary, where he was a member of the social fraternity the Kappa Alpha Order (commonly known as KA).
- Daughter, Charlotte Lawrence (Charlotte Sarah Lawrence), was born on June 8, 2000 in Los Angeles.
- Daughter Charlotte Lawrence is a musician.
- Graduated from Ben Franklin High School.
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