- Has starred in over 225 Telugu films in her entire career and had 25 films released in a single year.
- Niece of actress and director Vijaya Nirmala.
- Even though Telugu is her mother tongue, she never learned to read or write Telugu because she was born in Madras where Tamil and English are taught in schools. She acted in 225 Telugu films by having people read lines to her, and she would remember and deliver her lines.
- She married actor Jeetendra's cousin, a film producer named Nitin Kapoor, in 1985, claiming that it was their mutual love of cricket that made them close.
- Vijaya Nirmala convinced Jayasudha's disapproving father to let the stage-struck girl act in films, and that she personally would take care of her, and he finally relented.
- She claims that when she was a child, she was a very bad student and was only interested in films, dance, and cricket.
- Her first son Nihar was born in 1986, and her second son Sreyanth was born in 1990.
- Her sister Subhashini played supporting roles in several of Jayasudha's starrers, such as Sivaranjani (1978) and Meghasandesam (1983).
- Cousin of actor V.K. Naresh (son of Vijaya Nirmala).
- Writer-Director Dasari Narayana Rao cast her in nearly 30 films. He used her name in the song "Andalanni Neelone Daguyanni....Jayasudha" in the film Idekaddi Nyayam (1977) that was picturized on her. By 1982, she had become such a famous actress that he titled a film that she starred in Jayasudha (1982) named after her.
- The press documented her 50th birthday celebration, coinciding with a Christmas celebration, as she donated gifts to a charitable organization. (December 2008)
- Claims that she never had crushes on any of her many leading men, but instead fell in love with film producer Nitin Kapoor and married him.
- Is allergic to eggs and bemoans the fact that she can't eat pastries.
- Many of her relatives are actors: V.K. Naresh, Mahesh Babu, Namrata Shirodkar, Shilpa Shirodkar, Meenaxi, Ramesh Babu Ghattamaneni, Manjula Ghattamaneni, Jeetendra, Tusshar Kapoor, Ekta Kapoor. Abhishek Kapoor, Pragya Kapoor, Pooja.
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