Houser is the co-founder and vice president of creativity for Rockstar Games. He also works as the head writer for Rockstar Games. He got his start working for BMG Interactive, where he and his brother Sam Houser took interest in a game titled "Race'n'Chase", developed by DMA Design. The brothers signed the game to BMG Interactive as the publishers and changed the title to "Grand Theft Auto". After BMG Interactive was sold to Take-Two, the brothers moved to New York and founded Rockstar Games together.
Generally, the stories of his video games star criminals or antiheroes of moot morality.
As a producer, he regularly works with his brother Sam Houser and Leslie Benzies; as a writer, he regularly works with Rupert Humphries and Michael Unsworth.
Constant parody of American culture in their video games (especially in the Grand Theft Auto series).
On February 4, 2020, it was announced he would resign from Rockstar Games, taking effect on March 11, 2020, after being at the company for nearly 22 years.