- Turned down the role of "Carrie Bradshaw" on Sex and the City (1998). The part went to Sarah Jessica Parker.
- Speaks Gaeilge (traditional language of Ireland).
- Her great-grandfather invented the Delany valve, a flushing device still in use in toilets to this day.
- Has played the same character (Lois Lane) in three different series: Superman: The Animated Series (1996), Justice League (2001) and The Batman (2004).
- Although she is from New York City and is a stage-trained actress, she admitted in an interview that she prefers film and television work to stage work.
- Since the mid-1990s she has been serving on the board of Scleroderma Research Foundation, and is involved in the campaign to find a cure.
- When she moved to New York City in the 1970s, she worked as a cocktail waitress while waiting for her big break.
- In 1991 was chosen by "People" magazine as one of the 50 Most Beautiful People in the World.
- She was the voice of two superheroes' girlfriends: Andrea Beaumount, girlfriend of Bruce Wayne, in Batman: Mask of the Phantasm (1993); and Lois Lane in Superman: The Animated Series (1996).
- On 3/18/81 her father, who was her biggest fan, died from pancreatic cancer.
- Original choice for the role of "Bree" on Desperate Housewives (2004). Role went to her friend, Marcia Cross. They both appeared on Cheers (1982), but on different episodes.
- Auditioned to play "Jade Butterfield" in Endless Love (1981), and got the part. However, director Franco Zeffirelli turned her down because she wasn't a major movie star at the time, so Brooke Shields was cast instead.
- One of "People" magazine's Most Beautiful People in the World 2011.
- Her mother is related to Abraham Lincoln's Secretary of the Navy, Gideon Welles.
- Graduated from Wesleyan University.
- Starred in Desperate Housewives (2004) (2004-2012), alongside Teri Hatcher, with whom she shares the role of "Lois Lane". Both women also played the love interest of James Denton, who played the role of Lois Lane's love interest, Clark Kent/Superman in All-Star Superman (2011).
- Her first and last names are quoted in the final rhyme to the Animaniacs (1993) theme song.
- Has an older brother, Sean Delany, and a younger sister, Corey Delany.
- Attended Phillips Academy Andover for her senior year of high school.
- Attended Stamford, Connecticut, public schools until her senior year in high school.
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