- Best friends with his former brother-in-law Joaquin Phoenix.
- Younger brother of actor Ben Affleck.
- Attended Columbia University, majoring in Physics. During this time he lived with his grandma in Manhattan.
- Former brother-in-law of River Phoenix, Rain Phoenix, Joaquin Phoenix, Liberty Phoenix, and Jennifer Garner.
- Has 2 sons: Indiana Affleck (b. May 31, 2004) & Atticus Affleck (b. January 12, 2008) with ex-wife, Summer Phoenix.
- Appeared with brother Ben Affleck in the movies Chasing Amy (1997), Good Will Hunting (1997) and 200 Cigarettes (1999).
- The Afflecks are one of only two pairs of brothers to win Academy Awards in different categories. James Goldman won for adapted screenplay in 1968; the following year, William Goldman won for original screenplay.
- In the 2003 March issue of Nylon Magazine, admitted to not being proud of two movies in his career: Drowning Mona (2000) & Soul Survivors (2001).
- Separated from Summer Phoenix in November 2015. She filed for divorce in July 2017.
- Graduated from Cambridge Rindge and Latin School in June 1993.
- He and his brother Ben Affleck have both had on-screen romances with Liv Tyler: Lonesome Jim (2005), Armageddon (1998) and Jersey Girl (2004).
- As of 2024, he has appeared in three films that were nominated for the Best Picture Oscar: Good Will Hunting (1997), Manchester by the Sea (2016) and Oppenheimer (2023).
- His mother purchased work by Boston acclaimed photographer Brian Carroll as a gift to Casey, for the back-to-back premieres of Gone Baby Gone (2007) and The Assassination of Jesse James by the Coward Robert Ford (2007).
- Appeared with Matt Damon in seven films: Good Will Hunting (1997), Gerry (2002), Ocean's Eleven (2001), Ocean's Twelve (2004), Ocean's Thirteen (2007), Interstellar (2014) and Oppenheimer (2023).
- His ancestry is mostly English, Irish, German, Scottish, and Scots-Irish/Northern Irish, and distant/remote Swiss-German, Swedish, French, and Welsh. His maternal great-grandfather, Joseph Raymond Boldt, was born in Rhode Island, to German immigrants, and his maternal great-grandmother, Anne Rita Lenihan, was Irish, born in County Down.
- His great-great-grandfather Heinrich/Henry Boldt, as a twelve year-old, discovered the 10th century concave gold disc, the Curmsun Disc, at the Groß- Weckow village in Pomerania. He was playing with friends and found the door to the cellar crypt where the disc was located.
- Longtime neighbor of Dax Shepard.
- His older brother, Ben Affleck, and his fiancée's older brother, River Phoenix, have both played versions of characters played by Harrison Ford. Ben Affleck played Jack Ryan in The Sum of All Fears (2002), and River Phoenix played the young Indy in Indiana Jones and the Last Crusade (1989).
- Former son-in-law of Heart Phoenix.
- Born at 7:38 PM (EDT).
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