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| American Comedy Awards, USA | |||
| Year | Result | Award | Category/Recipient(s) |
|---|---|---|---|
| 2000 | Nominated | American Comedy Award |
Funniest Actress in a Motion Picture (Leading Role) for: Mystery Men (1999) |
| 1996 | Nominated | American Comedy Award |
Funniest Supporting Actress in a Motion Picture for: Bye Bye Love (1995) |
Funniest Supporting Female Performer in a TV Series for: "The Larry Sanders Show" (1992) |
| Annie Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 2008 | Nominated | Annie |
Best Voice Acting in an Animated Feature Production for: Ratatouille (2007) |
| Chlotrudis Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 1998 | Nominated | Chlotrudis Award |
Best Supporting Actress for: Romy and Michele's High School Reunion (1997) |
| Emmy Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 1997 | Nominated | Emmy |
Outstanding Supporting Actress in a Comedy Series for: "The Larry Sanders Show" (1992) |
| 1996 | Nominated | Emmy |
Outstanding Supporting Actress in a Comedy Series for: "The Larry Sanders Show" (1992) |
| MTV Movie Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 1997 | Nominated | MTV Movie Award |
Best Comedic Performance for: The Truth About Cats & Dogs (1996) |
| Montréal Comedy Festival 'Just for Laughs' | |||
| Year | Result | Award | Category/Recipient(s) |
| 2000 | Won | Jury Award |
Best Actress for: The Independent (2000) |
| Screen Actors Guild Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 2006 | Nominated | Actor |
Outstanding Performance by an Ensemble in a Drama Series for: "The West Wing" (1999) Shared with: Alan Alda Kristin Chenoweth Dulé Hill Allison Janney Joshua Malina Mary McCormack Janel Moloney Teri Polo Richard Schiff Martin Sheen Jimmy Smits John Spencer Bradley Whitford |
| Slamdunk Film Festival | |||
| Year | Result | Award | Category/Recipient(s) |
| 2001 | - | Lifetime Achievement Award | |
| Visual Effects Society Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 2008 | Won | VES Award |
Outstanding Animated Character in an Animated Motion Picture for: Ratatouille (2007) Shared with: Jaime Landes Konishi Sonoko Paul Aichele For "Colette". |