- Spends every Thanksgiving with Helen Hunt.
- When he was a teenager, studied ballet with his childhood friend Eric Stoltz in Santa Barbara, California, so that "they could meet girls."
- When Edwards received a large bonus from the producers of ER, he donated a large portion of it to the Santa Barbara Junior High School for the renovation of its theater, later named in honor of his middle school drama teacher, Marjorie Luke. The Theater is now home to numerous plays and performances not only for the Junior High School, but also for the entire community.
- His grandfather designed Walt Disney Studios in the 1930s.
- His ex-wife, Jeanine Lobell, is a respected & renowned make-up artist who also founded the Stila cosmetics line.
- Was approached by Michael Crichton (author of "Jurassic Park") and producer John Wells to star in a two-hour pilot called ER (1994) after playing a lawyer in The Client (1994).
- Plays basketball with friend George Clooney, who also co-starred with him on ER (1994).
- Owns his production company, Aviator Films
- Is currently on the Board of Cure For Autism Now Foundation.
- Had a relationship with Meg Ryan [1986-1987].
- Driver of Pace Car at 84th Indianapolis 500, May 28, 2000.
- Has four children: Son Bailey (born June 1, 1994), daughters Esme and Wallis born (September 1, 2000) and daughter, Poppy (born March 15, 2002) with wife Jeanine Lobell.
- Is an honorary board member of Access Theatre, a repertory acting company comprised of disabled artists. A documentary he directed about this group has received several awards and is being distributed in high schools around the United States.
- His parents wouldn't allow him to watch prime-time TV as a teenager.
- Is good friends with Aimee Mann and Natalie Portman.
- (1986 - 88) Graduated from University of Southern California with a BA in drama
- Had watched every single Gene Kelly musical, which led him to becoming "a song and dance man".
- Grew up and went to school with Eric Stoltz and Linus Huffman.
- Attended Santa Barbara Jr. High with Kathleen Wilhoite who co-starred in several episodes of ER (1994) as "Chloe Lewis".
- Is a big fan of South Park (1997).
- Named as "Favorite Male Television Performer in a Series" by the People's Choice Awards.
- Has a cat named Nitro.
- Anthony's father was of English, Irish, Scottish, and one quarter Spanish-Mexican, ancestry. Anthony's maternal grandfather was German, and Anthony's maternal grandmother was born in China, to German parents.
- Moved to Manhattan, New York, in 2002
- Named "The Sexiest Man" in a prime-time series [1997].
- Is a big fan of race car driving.
- As a teenager, he collected James Taylor's and Styx's tapes/records.
- Attended San Marcos High School in Santa Barbara, California and graduated in 1980 (as stated on wall of fame plaque in auditorium).
- Was raised in "The Riviera", Santa Barbara's answer to Beverly Hills. His family belonged to the Riviera Country Club.
- His maternal grandfather, Kem Weber (Karl Emanuel Martin Weber), who was born in Berlin, was a prominent furniture/industrial designer, teacher, art director, and architect, and his maternal great-grandfather, Alfred Forke, was a Sinologist and UC Berkeley professor.
- Has expressed regrets about appearing in Top Gun (1986) because he feels the film contributed to a militaristic and warmongering mindset that he is personally opposed to.
- Nominated for best actor by the Viewers for Quality Television.
- At 16, he appeared in dozens of plays
- Best known by the public for his starring role as Dr. Mark Greene on [ER (1994)].
- Nominated as "Best Actor" by Cable Ace for his part in Sexual Healing (2006).
- Honda Civic was his very first car.
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Fast Times at Ridgemont High (1982) and Top Gun (1986).
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