- Her parents were the first married couple at Harvard Law School, where they were both enrolled.
- Born to Russell L. Brenneman, an environmental lawyer, and his wife Frederica S. Brenneman, the first female Senior Judge on the Superior Court of the State of Connecticut.
- Graduated from Harvard University in 1986, majoring in comparative religion.
- Tyne Daly was her co-star on Judging Amy (1999) (1999-2005),Tyne's brother Tim Daly appeared with her on Private Practice (2007) (2007-2013).
- Gave birth to her second child, a boy, Bodhi Russell Silberling, on 8 June 2005.
- One of the founding members of the Cornerstone Theater Company, Inc. in Los Angeles together with her husband Brad Silberling.
- Best friends with Maria Bello.
- On her father's side, she is of Swiss-German, German, English, Irish, and Scottish ancestry. On her mother's side, she is of Ashkenazi Jewish descent (from Germany, Russia, and Lithuania [where her maternal grandmother was born]). Amy's patrilineal ancestry can be traced back to Melchior Brenneman and Elizabeth Jane Stehman, who were emigrants from Bern, Switzerland to New Danville, Lancaster County, Pennsylvania, in the 1700s.
- Amy has two older brothers. Matthew, a lawyer; and Andrew, an interactive software producer.
- Daughter, Charlotte Tucker, was born weighing 7lbs 12oz, a special needs child with a rare chromosomal abnormality. (March 20, 2001)
- Pro-choice activist.
- Recently spoke at the March for Women's Lives rally in Washington, DC.
- Portrayedthe quirky "Dr. Violet Turner" on ABC's Private Practice (2007). The show aired 2007-2013. (October 2007)
- Graduated from Glastonbury High School, Glastonbury, Connecticut, in 1982.
- Announced in January 2005 that she is expecting her second child in the spring.
- Has played a character called "Amy" in two different shows: Judging Amy (1999) and in the Murder, She Wrote (1984) episode, A Christmas Secret (1992).
- Guest-starred on the Grey's Anatomy (2005) spin-off Private Practice (2007) in May 2007.The show joined the regular ABC lineup in September 2007, ending in 2013.
- Performing in Caryl Churchill's "Top Girls" January 11-15, 2006 with Theatre Works in Los Angeles. (January 2006)
- Starring in John Belluso's "A Nervous Smile" at The Williamstown Theatre Festival in Williamstown, MA with Gloria Reuben, Scott Cohen and Deirdre O'Connell. (August 2006)
- Husband Brad Silberling was the boyfriend of actress Rebecca Schaefer ("My Sister Sam"), who was murdered by a stalking fan in 1989. The 2002 film " Moonlight Mile," written and directed by Brad, was a fictional recounting of Rebecca's murder, from Brad's point of view.
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