- Born Julie Anne Smith, she had to change her name when she registered with the Actors Guild as every variation of her name seemed to be taken. She then combined her first two names and assumed her father's middle name as her surname.
- She didn't learn to swim until she was 26, and only learned to drive at age 27.
- She reads every script she receives.
- Ralph Fiennes, her co-star in The End of the Affair (1999), said of her, being interviewed for Ralph Fiennes (2006): "Julianne Moore has the most extraordinary spirit to act opposite. And funny, and sense of humor - we giggled a lot. I felt so relaxed with her. And her humor - not only her great talent, but her humor. A great friendship, and I am still friends with Julianne. So that's changed me, I've made a friend who I trust and love and would love to work with again.".
- Her father was a lawyer in the United States Army, and the family moved 23 times before she turned 18. She went to nine different schools.
- After Jodie Foster turned down the chance to reprise her Oscar-winning role of Clarice Starling in Hannibal (2001), several actresses were considered for the part. Moore triumphed over such contenders as Helen Hunt, Gillian Anderson and Cate Blanchett.
- In an interview for Julianne Moore (2002), she stated that Ralph Fiennes is her favorite leading man. They portrayed lovers in The End of the Affair (1999).
- A relatively late bloomer, Julianne didn't learn to drive until she was 27, appeared in her first feature film at age 30, and waited until she turned 37 to start a family.
- Received a star on the Hollywood Walk of Fame at 6250 Hollywood Boulevard in Hollywood, California on October 3, 2013.
- Graduated from Frankfurt American High School in Frankfurt, Germany in 1979.
- Is a big fan of Downton Abbey (2010). She co-starred with the star of the series Michelle Dockery in Non-Stop (2014), and on the set of the film, she would ask Dockery for possible spoilers and secrets of the show.
- In order to convincingly portray the role of a housewife suffering from an immune disorder in Safe (1995), she lost 10 pounds off of her already petite frame.
- Along with Fay Bainter, Teresa Wright, Barry Fitzgerald, Jessica Lange, Sigourney Weaver, Al Pacino, Holly Hunter, Emma Thompson, Jamie Foxx, Cate Blanchett and Scarlett Johansson, she is one of only twelve actors to receive Academy Award nominations in two acting categories in the same year. She was nominated for Best Actress for Far from Heaven (2002) and Best Supporting Actress for The Hours (2002) at the 75th Academy Awards in 2003.
- As of 2015, has appeared in three films that were nominated for the Best Picture Oscar: The Fugitive (1993), The Hours (2002) and The Kids Are All Right (2010).
- Chose to remain uncredited in her role as the voice of "Aria" in Eagle Eye (2008).
- Her very first role on stage came in sixth grade when she played the Little Red-Haired Girl in "You're a Good Man, Charlie Brown" at Anne M. Dorner Middle School in Ossining, New York. She was scared and did not like it.
- $127,000 worth of jewelry was stolen from her New York City apartment. (October 4, 2012)
- She and Eddie Redmayne played mother and son in Savage Grace (2007). In 2015, both won the Best Actor and Best Actress Oscar, respectively.
- Worked briefly as part-time waitress in Boston, Massachusetts.
- In 2003, when she was nominated for two Oscars, she was in competition with her co-stars from The Hours (2002); Nicole Kidman (for The Hours (2002)) and Meryl Streep (for Adaptation. (2002)). Kidman won for Best Actress.
- Lived in Juneau, Alaska, for about a year and a half and attended school there from 1971-1972.
- Currently lives with her family in Greenwich Village, New York City. (2009)
- Was 4 months pregnant with her daughter, Liv Freundlich, when she completed filming on Far from Heaven (2002).
- Counts actor Michael Fassbender as a cinematic crush.
- Received triple nominations from the Screen Actors Guild Awards in both 2000 and 2003.
- Was one month pregnant with son Cal Freundlich when she completed filming The Big Lebowski (1998).
- She's a natural redhead.
- Graduated from Boston University's School of the Arts.
- Her favorite movie is Rosemary's Baby (1968).
- Andre Gregory, who directed her onstage in "Uncle Vanya", said that "she evoked the sensuality and urgency of a young Joan Crawford, but with more depth, more contradictions".
- Has appeared in Boogie Nights (1997), The Big Lebowski (1998) and Magnolia (1999) with Philip Seymour Hoffman. Both of them have played characters in the Hannibal Lecter series. Moore played Clarice Starling in Hannibal (2001), and Hoffman played Freddie Lounds in Red Dragon (2002).
- 12/4/97: Son Cal Freundlich born. Father is Bart Freundlich.
- Julianne's father, Peter Moore Smith, was born in New Jersey, to Charles Edward Smith, Jr. and Frances Mervil Haas; Julianne's father's ancestry is German, as well as Irish, English, Welsh, and one eighth German-Jewish. Julianne's mother, Anne (Love), was born in Greenock, Scotland, to Henry McNeil Love and Flora McMillan McLean. Julianne's mother's family moved to New Jersey in 1951.
- She and Joan Cusack played pregnant women in Nine Months (1995). In 1997, their own sons were born.
- The fourth actor overall and the second actress to have achieved the rare feat of winning an acting prize in the three major film festivals: 2002 Volpi Cup Best Actress for Far from Heaven (2002), 2003 Silver Bear Best Actress for The Hours (2002) (shared with Nicole Kidman and Meryl Streep), and 2014 Cannes Best Actress for Maps to the Stars (2014). The others actors to achieve this feat are Jack Lemmon, Sean Penn, and Juliette Binoche. Additionally, all four actors have won acting Oscars.
- Her mother, Ann Love Smith, died on April 29, 2009 at age 68.
- Moved into $900,000 3-bedroom loft in Greenwich Village. (November 1999)
- Moved into $2.65-million duplex penthouse in Greenwich Village, New York City. (2002)
- Has starred in three films nominated for Best Picture at the Academy Awards: The Fugitive (1993) (albeit briefly), The Hours (2002) and The Kids Are All Right (2010).
- Is one of 13 actresses to have won the Academy Award, BAFTA Award, Critics' Choice Award, Golden Globe Award and SAG Award for the same performance. The others in chronological order are Julia Roberts for Erin Brockovich (2000), Renée Zellweger for Cold Mountain (2003), Reese Witherspoon for Walk the Line (2005), Helen Mirren for The Queen (2006), Jennifer Hudson for Dreamgirls (2006), Kate Winslet for The Reader (2008), Mo'Nique for Precious (2009), Natalie Portman for Black Swan (2010), Octavia Spencer for The Help (2011), Anne Hathaway for Les Misérables (2012), Cate Blanchett for Blue Jasmine (2013) and Patricia Arquette for Boyhood (2014).
- Her younger brother, Peter Moore Smith, is an author and has written the book "Raveling", for which Moore has bought the film rights. She also has a younger sister named Valerie.
- Chosen as one of People Magazine's "50 Most Beautiful" list. (2001)
- Husband Bart's family name "Freundlich" is German for "friendly".
- Her father was a judge in the Army's Judge Advocate General Corps and her mother was a psychiatric social worker.
- Was the 144th actress to receive an Academy Award; she won the Best Actress Oscar for Still Alice (2014) at The Oscars (2015) on February 22, 2015.
- Has an "obsession" with furniture designers Paavo Tynell and Harvey Probber.
- Artist ambassador for "Save the Children".
- Of the four acting winners at The Oscars (2015), she was the only one with a previous nomination.
- The longest she has gone without an Oscar nomination is the 12 years between her double nomination for Far from Heaven (2002) and The Hours (2002) and Still Alice (2014).
- Louis Malle, who directed her in Vanya on 42nd Street (1994), said that "she made him think of the greatest of all ravaged beauties, Jeanne Moreau".
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