Christina Applegate and Jennifer Esposito in Samantha Who? (2007)

Christina Applegate and Barry Watson in Samantha Who? (2007)

Christina Applegate in Samantha Who? (2007)

Christina Applegate, David Schwimmer, and Aisha Tyler in Friends (1994)

Gwyneth Paltrow, Christina Applegate, and Stacey Dash in View from the Top (2003)

Gwyneth Paltrow, Kelly Preston, and Christina Applegate in View from the Top (2003)

Gwyneth Paltrow and Christina Applegate in View from the Top (2003)

Christina Applegate, Matthew Perry, and David Schwimmer in Friends (1994)

Christina Applegate, Courteney Cox, and Matt LeBlanc in Friends (1994)

Christina Applegate, Matt LeBlanc, Matthew Perry, and David Schwimmer in Friends (1994)

Jennifer Aniston and Christina Applegate in Friends (1994)

Cameron Diaz, Christina Applegate, and Selma Blair in The Sweetest Thing (2002)

Cameron Diaz and Christina Applegate in The Sweetest Thing (2002)

Christina Applegate and Linda Cardellini in We've Been Here Before (2022)

Christina Applegate and Linda Cardellini in Where Do We Go Now? (2022)

Christina Applegate in Saturday Night Live (1975)

Christina Applegate and Matt LeBlanc in Married... with Children (1987)

Christina Applegate, Will Ferrell, and Fred Willard in Anchorman: The Legend of Ron Burgundy (2004)

Christina Applegate in Married... with Children (1987)

Christina Applegate and Linda Cardellini in Dead to Me (2019)

Christina Applegate, Joe Don Baker, Lukas Haas, Jack Black, O-Lan Jones, and Sylvia Sidney in Mars Attacks! (1996)

Christina Applegate and Kevin Mangan in Mars Attacks! (1996)

Harrison Ford, Christina Applegate, and Will Ferrell in Anchorman 2: The Legend Continues (2013)

Christina Applegate in Web Therapy (2011)

Christina Applegate and Nina Dobrev in Crash Pad (2017)

Christina Applegate, Thomas Haden Church, and Nina Dobrev in Crash Pad (2017)

Christina Applegate in Tilt-A-Whirl (2005)

Christina Applegate in The Giving Tree (2000)

Matt Dillon, Christina Applegate, and Steve Zahn in Employee of the Month (2004)

Christina Applegate, Will Ferrell, Steve Carell, David Koechner, and Paul Rudd in Anchorman: The Legend of Ron Burgundy (2004)

Christina Applegate in Suzanne's Diary for Nicholas (2005)