Affable hillbillies Tucker and Dale are on vacation at their dilapidated mountain cabin when they are mistaken for murderers by a group of preppy college students.
Five college friends head out to a remote cabin for a getaway, but things don't go as planned when they start getting killed. They soon discover that there is more to the cabin than it seems.
A newly-possessed high-school cheerleader turns into a succubus who specializes in killing her male classmates. Can her best friend put an end to the horror?