Grey's Anatomy Episodes
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- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe first shift for new surgical interns Meredith, Cristina, Izzie, George, and Alex proves eventful and backbreaking.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglA rape victim is admitted, who managed to hold onto part of her attacker; Izzie has difficulty with a patient who cannot speak English; Meredith becomes concerned about a sick baby.
- DirectorTony GoldwynStarsEllen PompeoSandra OhKatherine HeiglIzzie and Cristina are assigned a close-to-brain-dead John Doe who may be a viable candidate for organ donation, and helpful to George's patient, who needs a new liver. Meanwhile, Meredith and Alex butt heads over a patient of their own.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglAlex uses Izzie's modeling against her, and her last ad causes a patient to reject her care. Meredith finds parallels between a patient and her mother, and Christina must deal with a hospital-savvy patient.
- DirectorJohn David ColesStarsEllen PompeoSandra OhKatherine HeiglMeredith worries she did something wrong during a heart bypass, an error in a past procedure is discovered, putting a staff member's conduct under scrutiny, while a party thrown by Izzie to introduce her boyfriend becomes a fiasco.
- DirectorScott BrazilStarsEllen PompeoSandra OhKatherine HeiglA woman with a massive tumor is admitted, with all the surgeons required to scrub in. In their absence, Meredith is assigned a patient with Parkinson's and, because Alex's pager is not working, Izzie is left in charge of the floor herself.
- DirectorDarnell MartinStarsEllen PompeoSandra OhKatherine HeiglIzzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
- DirectorSarah Pia AndersonStarsEllen PompeoSandra OhKatherine HeiglMeredith wants to learn more about Derek, but he remains cagey. Meanwhile, a supposedly psychic patient proves bothersome, Alex must convince a young girl to agree to a life saving operation, and Cristina is conflicted about her pregnancy.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglGeorge finally gets laid but gets syphilis. It's rampant among staff. Surgeon Webber is losing his sight. He wants Shepherd to operate secretly. A male patient has an ovary. A lifesaving autopsy's performed without consent.
- 2005– 43mTV-148.3 (1.7K)TV EpisodeDirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglMeredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglA family is admitted after being involved in a car crash, but there is more to them than meets the eye. Meanwhile, Bailey and her team deal with a strange case, and relationship woes plague Meredith, Cristina and George.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglMeredith is horrified when her mother is admitted, and everyone is concerned when Cristina collapses in the operating room. Meanwhile, Addison is determined to save a very sick baby.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglCristina is determined to get back to work, and despite not being fully recovered, she manages to crack an odd case. Meanwhile, Addison offers to help Bailey with a complicated surgery, and Alex receives important news.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglA storm rages, causing power outages and jamming the elevator, trapping George and Alex inside with a vulnerable patient. Meanwhile, Meredith and Derek arrange a religious ritual for a young woman, and Cristina deals with an unusual case.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglA train wreck brings in multiple casualties, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his mojo a disheartening experience, and Cristina searches high and low for a missing appendage.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglDerek reluctantly attends marriage counseling with Addison, while Meredith, Izzie and Cristina steal a patient with an unusual problem. Alex helps a young patient gain her independence, and Cristina thinks Bailey knows about her and Burke.
- DirectorLesli Linka GlatterStarsEllen PompeoSandra OhKatherine HeiglFriends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.
- DirectorMichael DinnerStarsEllen PompeoSandra OhKatherine HeiglThanksgiving sends the occupants of Meredith's house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner to which it appears no one is coming.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglMeredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe mother of the quints blames herself. Meanwhile, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina takes care of an inmate desperate to stay at the hospital.
- 2005– 1hTV-148.1 (1.4K)TV EpisodeDirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglChristmas hits Seattle, with Izzie caring for a man who fell from his roof while hanging decorations. Meanwhile, Cristina helps perform a heart transplant on a depressed boy, and George has to contend with the family from Hell.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglIzzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglMeredith must choose between her dog and her roommates. Meanwhile, George deals with an elderly patient who has outstayed her welcome, Bailey's pregnancy has complications, Alex gets his exam results, and Richard has a strike on his hands.
- DirectorDavid PaymerStarsEllen PompeoSandra OhKatherine HeiglThe nurses are striking, and George refuses to cross the picket line. The interns are surprised by Bailey's seemingly immature replacement, Izzie connects with a pregnant girl, and an elderly woman's plight pushes Meredith to the limit.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe lives of everyone in the OR are threatened when a patient enters with a bomb inside him, and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglWhile the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglDerek and Addison are shaken by the arrival of a figure from their past. Meanwhile, Burke learns Cristina's secret, Izzie deals with a very unusual case, Meredith delves into her family's dirty laundry, and George pours his heart out.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglMeredith and George face the consequences of their actions, Izzie gets closer to Denny, who has been readmitted, and Addison asks for Bailey's help with an embarrassing ailment.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglCristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.
- DirectorTricia BrockStarsEllen PompeoSandra OhKatherine HeiglSuperstition strikes, with the interns convinced a series of deaths will occur. A complication from the LVAD surgery puts Denny in the OR, Cristina plans to make George move out, and Richard's old AA sponsor is admitted for treatment.
- DirectorSeith MannStarsEllen PompeoSandra OhKatherine HeiglCristina is desperate for George to move out of the apartment, while Izzie is jealous of Callie's relationship with him. Meanwhile, Cristina and Richard are rivals in a surgery seminar, and Meredith discovers a secret about her father.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglMeredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
- DirectorTony GoldwynStarsEllen PompeoSandra OhKatherine HeiglThe victims of a serious car accident are admitted, with every surgeon required to help. Meanwhile, Callie's forwardness grates on Izzie, Addison makes Alex suffer, and Derek takes his frustration out on Meredith.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe victims of a workplace shooting are admitted. Izzie puts her job on the line to ensure Denny gets a new heart, Callie makes an effort with Meredith, and Addison is suspicious of Derek.
- 2005– 1hTV-149.0 (1.9K)TV EpisodeDirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglBurke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglRichard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglEveryone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglIzzie copes with her grief by baking furiously, and George has to deal with an obstinate patient. Meanwhile, Meredith must choose between Derek and Finn, Addison drowns her sorrows in alcohol, and Cristina meets Burke's difficult mother.
- DirectorAdam ArkinStarsEllen PompeoSandra OhKatherine HeiglIzzie returns to the hospital, but finds it difficult to go inside, and George is tired of Callie's presence at home. Meanwhile, Addison cannot seem to get rid of Mark, and Cristina tries to cope with caring for Burke.
- DirectorDan LernerStarsEllen PompeoSandra OhKatherine HeiglMeredith becomes a patient, and Derek and Addison are equally angry at Richard for allowing Mark to join the staff. Meanwhile, Izzie receives a visit from Denny's father, and Burke is plagued by doubt over his ability to return to surgery.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglGuilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglIzzie returns to the hospital under probation, and George tries to make amends with Callie. Meanwhile, Cristina's deletion of Bailey's name on Burke's OR board makes her assume he is against her, and Derek's irritating sister Nancy visits.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglDerek, George, Alex, Burke, Richard, Joe and Walter go on a camping trip. Meanwhile, Meredith assists Mark with gender reassignment surgery, Izzie avoids discussing her grief, Addison works with Callie, and Cristina feels Bailey's wrath.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglGeorge must deal with his family's presence when his father is admitted. Meanwhile, Burke's secret is almost out, Alex tries to get close to Izzie again, and Richard comes to a decision about his marriage.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglA traumatic car accident fills the ER. Cristina has a crisis of conscience about her deceptive teamwork with Burke, Izzie pushes the boundaries of her probation, and Callie tries to explain herself to George.
- DirectorSeith MannStarsEllen PompeoSandra OhKatherine HeiglBailey is adamant that Burke and Cristina should be punished, Derek doubts his abilities, Izzie tries to take a stand against Mark's patronizing behavior, and Meredith deals with family in two very different ways.
- DirectorGreg YaitanesStarsEllen PompeoSandra OhKatherine HeiglAs George's father's surgery approaches, he begins to realize how serious his condition is. Meanwhile, Izzie has to prove to Bailey that she is ready to scrub in on a surgery, and Meredith keeps running into her father.
- DirectorGreg YaitanesStarsEllen PompeoSandra OhKatherine HeiglGeorge's father's surgery has left him very weak, Izzie's act of generosity backfires on her, Cristina and Burke continue their war of silence, and Meredith reaches out to her father.
- DirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglGeorge deals with his grief, Cristina and Burke continue to ignore each other, Addison avoids Alex, and Izzie decides to help Bailey with a project. Meanwhile, Richard makes a decision which sends all the attendings scrambling.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglA toxic patient wreaks havoc. Meanwhile, Bailey opens the free clinic, but the lack of patients makes Izzie question her investment. Meredith's mother is admitted again, and Cristina makes Burke wait for an answer.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe interns each react differently to a mass-casualty incident. Meanwhile, George crosses the professional line with Callie, Cristina asks Burke to keep quiet about their engagement, and Richard dons a new hairstyle.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglIzzie fights to save her patient's life, George searches for the son of his patient, and Alex has to contend with the relatives of victims. Meanwhile, Meredith is unconscious underwater, with Derek her only hope.
- DirectorAdam ArkinStarsEllen PompeoSandra OhKatherine HeiglAn unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglA Korean war veteran with a bullet lodged in his shoulder is admitted. Meanwhile, tensions escalate between Izzie and George, Callie reveals a big secret, Cristina contends with an old flame, and Alex continues to work with the Jane Doe.
- DirectorTamra DavisStarsEllen PompeoSandra OhKatherine HeiglThe attendings face their board interviews. Meanwhile, Izzie seems to be the only one who remembers the night before, Derek is overly protective of Meredith when Mark offers her a surgery, and Callie's father pays a visit.
- DirectorChristopher MisianoStarsEllen PompeoSandra OhKatherine HeiglMeredith deals with her over protective stepmother, Cristina is caught between Burke and Marlow, and Derek fights to become Chief. Meanwhile, Alex continues the search for Jane Doe's identity, and Izzie's past comes back to haunt her.
- DirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglThe Chairman of Seattle Grace's board of directors is admitted, and the attendings vie for his favor, while the interns study for exams. Izzy and George are reminded of their infidelity, and Burke presses Cristina about wedding plans.
- 2005– 1hTV-146.9 (1.5K)TV EpisodeDirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglAddison heads for warmer climate to figure things out, Meredith's stepmother visits the clinic, Cristina's perfect wedding is challenged when she and Burke's mothers visit, and Izzie tries to talk to George.
- 2005– 1hTV-147.2 (1.4K)TV EpisodeDirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglAddison is pulled into the case of a high-risk surrogate mother, Meredith's stepmother develops a complication, Izzie struggles with George's decision, and Ava has surgery which may restore her memory.
- DirectorChristopher MisianoStarsEllen PompeoSandra OhKatherine HeiglThe interns face their first year medical exams. With the interns busy, the attendings must do their own legwork, Burke appoints a new best man, Cristina writes her vows, and Callie grows suspicious of George and Izzie.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe wedding day arrives. Richard chooses the new Chief and Chief Resident, the interns receive their exam results, Callie drops a bombshell on George while Izzie pours her heart out to him, and Burke makes an important decision.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe interns, now residents, deal with their own crops of interns. Callie struggles with her new position, and Burke makes a decision.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglLexie persists in trying to get to know Meredith, and Mama Burke descends once more.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglCallie hides in her office, frustrating Bailey who's itching to teach someone. Elsewhere, age becomes the theme as Izzie tries to convince 'Really Old Guy' he shouldn't die, Webber and Sloan set out to prove they're not too old to learn a new technique, and Karev is saddled with an intern who's past his prime.
- DirectorRandy ZiskStarsEllen PompeoSandra OhKatherine HeiglMeredith and her intern lose a patient after they give her the wrong diagnosis, Callie confronts Izzie, and McDreamy bonds with the other Grey.
- DirectorBethany RooneyStarsEllen PompeoSandra OhKatherine HeiglMeredith feels she's being haunted by her Mother's ashes, and Cristina is denied a surgery for a surprising reason.
- DirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglA man survives a parachute accident without serious injury, two women refuse treatment because of a wedding contest, and Cristina and Izzie jockey for inclusion in Hahn's surgeries.
- 2005– 1hTV-147.8 (1.2K)TV EpisodeDirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglHahn bans Cristina from her service, Bailey covers more and more of Torres' duties, and Izzie and George go to extreme lengths to recapture the magic of their first encounter.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglBailey crosses the line when the guy she had a crush on in high school shows up in the ER during an onslaught of high school students involved in a bus crash. The Grey sisters run and hide when their father shows up drunk, while Derek tries to get back into the dating scene with another doctor and Cristina tries her best to get back into Hahn's good graces.
- DirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglAn accident in the ER bay leaves two paramedics fighting for their lives, and a third who refuses Bailey's care. Meanwhile, Alex juggles two women, and Lexie begins to bond with a patient.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglTragedy abounds for everyone at Seattle Grace as they all continue in efforts to get the paramedic out of the overturned ambulance, stop the bleeding of a man who won't quit, and a bigot with a Nazi tattoo on his stomach. On the personal side, Rebecca returns to spend time with Alex, Miranda's husband finds it harder to wait for her while she's in surgery, and Cristina still tries to get on Hahn's good side, even though Bailey has put her elsewhere.
- DirectorJohn TerleskyStarsEllen PompeoSandra OhKatherine HeiglBailey's son comes to the ER, Derek takes a housing step that puts pressure on Meredith, Izzie has a crisis of faith, and Cristina's choice may change her course with Hahn.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe judgment of the residents is skewed by a competition, Meredith tries therapy and a bear attack may be more than it appears.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglAddison is not prepared for all the changes that greet her upon her return to Seattle Grace for a specialized surgery, Meredith and Derek begin their clinical trial, Izzie feels left out, and Karev is confronted with an unexpected announcement.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglThe new clinical trial patient has a secret, Yang is dealt a blow from a distance by Burke, the nurses refuse to work with Sloan, and Meredith's therapist tells her some home truths.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglCristina is still in her slump and turning mean, Izzie finally confronts Ava/Rebecca, and Meredith's anger with her therapist is challenged by a patient with a Cinderella story.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglMeredith and Derek are at odds over whether or not to continue with their 13th clinical trial patient and the doctors lift the final critical pieces of cement from the young boy's body. Meanwhile, Alex rushes Ava into the hospital and is forced to confront the reality of her condition.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglA surgical team battles the clock as they try to save a boy encased in cement, Karev's situation with an ever-disintegrating Ava brings back painful memories that interfere with his judgment, Derek and Meredith have one last chance at their clinical trial.
- 2005– 1hTV-148.1 (1.4K)TV EpisodeDirectorRob CornMichael PressmanStarsEllen PompeoSandra OhKatherine HeiglMeredith and Derek find that "happily ever after" isn't as easy as they hoped, Cristina finds interest in a military doctor, and the Chief is surprised to hear that Seattle Grace is no longer ranked as a top-tier teaching hospital.
- 2005– 1hTV-148.2 (1.1K)TV EpisodeDirectorRob CornMichael PressmanStarsEllen PompeoSandra OhKatherine HeiglAs a group of best friends deal with the aftermath of their car crash, Dr. Torres takes the lead on a groundbreaking course of treatment for one of the patients. Meanwhile, Major Hunt starts to irritate other attendings with his presence in the hospital.
- DirectorMichael PressmanStarsEllen PompeoSandra OhKatherine HeiglThere is a huge problem affecting the whole hospital including patients too. Richard is trying to do his best to solve the problem.
- DirectorEric StoltzStarsEllen PompeoSandra OhKatherine HeiglCallie worries over her first real date with Erica. Cristina stumbles upon a neglected area of the hospital.
- DirectorRandy ZiskStarsEllen PompeoSandra OhKatherine HeiglBailey's dream of a domino surgery crumbles when one of the donors learns of her husband's affair. Meredith is insulted when she gets no credit for the procedure she and Derek worked on together.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglThe new trauma surgeon shocks everyone with his methods, Bailey is asked to save a girl with an inoperable tumor, and Callie's not sure what she wants.
- DirectorJoanna KernsStarsEllen PompeoSandra OhKatherine HeiglThe residents and interns squabbling over procedures upsets Dr. Hunt, Erica discovers what happened to the heart she lost, and Derek asks Sloan to break out the McSteamy to distract Yang.
- DirectorEric StoltzStarsEllen PompeoSandra OhKatherine HeiglIzzie wrestles with her ghost, Torres uses a ground-breaking procedure to get her mind off of Hahn, and the interns continue teaching themselves spurred on by a new cohort.
- DirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglSadie manipulates the interns into performing a procedure that goes horribly wrong, Izzie's ghost refuses to leave, and Mark bonds with a girl who's taken responsibility for her sleep-walking father.
- DirectorArlene SanfordStarsEllen PompeoSandra OhKatherine HeiglThe residents make their cases for the solo surgery, Sadie chafes at her restrictions, and Sloan battles his desires.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglDerek has trouble with objectivity concerning his death row patient, Cristina and Meredith continue their feud, Izzie confides her problem to Alex, and the Chief faces what's become of his life's work.
- DirectorJeannot SzwarcStarsEllen PompeoSandra OhKatherine HeiglDerek's mother visits, the death row patient starts angling for death in the hospital, Izzie craves more in her relationships, and Jackson's need for organs becomes critical.
- DirectorAllison Liddi-BrownStarsEllen PompeoSandra OhKatherine HeiglMeredith and Miranda each cross a line, William Dunn regrets his decision and Izzie finally confronts what Denny's appearance means.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglCristina carries on an intense flirtation with Owen, Derek gets advice from everyone on how to propose, Izzie gets some tests done, and Bailey's promotion may stand in the way of a new career possibility.
- DirectorDaniel AttiasStarsEllen PompeoSandra OhKatherine HeiglOwen runs into someone very special from his past. Izzie employs her fellow doctors in a medical game made to help teach the interns. Naomi, Sam and Addison rush Archer to Seattle Grace and meet with Derek and Mark to save his life.
- DirectorRandy ZiskStarsEllen PompeoSandra OhKatherine HeiglAddison and Derek differ on the treatment plan for their patient, Cristina discovers malpractice in high places, Izzie gets bad news, and Mark spectacularly mistimes his confession.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglDerek's malpractice deposition reveals an unhappy statistic, the interns finally diagnose 'Patient X', Karev stands up to two attendings to save a band geek, and when Webber shuts Miranda out completely she makes a call.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglSloane's facial transplant fades to the background as the interns begin squabbling, Bailey's attempts to reach Derek unexpectedly clear surgeons from the hospital, and Cristina juggles her first solo surgery with treating a resistant Izzie.
- DirectorEdward OrnelasStarsEllen PompeoSandra OhKatherine HeiglOwen's PTSD endangers Cristina, Izzie's illness leaves the residents dealing with guilt and anger - at her expense, and Derek's fear causes him to persevere for Meredith's answer.
- DirectorTony PhelanStarsEllen PompeoSandra OhKatherine HeiglIzzie bites off more than she can chew on her first day of chemotherapy, Mark and Derek are forced to work on the same patient, Meredith's plans for a simple wedding take a turn, and Karev finds himself split between worry over Izzie and excelling as a resident.
- 2005– 1hTV-148.3 (1.2K)TV EpisodeDirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglIzzie's mother comes to town, a little girl shoots her father triggering a conflict between Meredith and the chief, Thatcher reappears, and Callie gets her first taste of life without her trust fund.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglA car crash involving students going to their college graduation takes its toll on the residents in the ER, Derek's wedding gift is uniquely suited for Meredith - even if the oversight is not. Meanwhile, Denny's return has Derek and Bailey searching for the cause, and the results will change the outcome of the day.