Denny & Izzie
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- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglIzzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglMeredith and George face the consequences of their actions, Izzie gets closer to Denny, who has been readmitted, and Addison asks for Bailey's help with an embarrassing ailment.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglCristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.
- DirectorTricia BrockStarsEllen PompeoSandra OhKatherine HeiglSuperstition strikes, with the interns convinced a series of deaths will occur. A complication from the LVAD surgery puts Denny in the OR, Cristina plans to make George move out, and Richard's old AA sponsor is admitted for treatment.
- DirectorSeith MannStarsEllen PompeoSandra OhKatherine HeiglCristina is desperate for George to move out of the apartment, while Izzie is jealous of Callie's relationship with him. Meanwhile, Cristina and Richard are rivals in a surgery seminar, and Meredith discovers a secret about her father.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglMeredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
- DirectorTony GoldwynStarsEllen PompeoSandra OhKatherine HeiglThe victims of a serious car accident are admitted, with every surgeon required to help. Meanwhile, Callie's forwardness grates on Izzie, Addison makes Alex suffer, and Derek takes his frustration out on Meredith.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe victims of a workplace shooting are admitted. Izzie puts her job on the line to ensure Denny gets a new heart, Callie makes an effort with Meredith, and Addison is suspicious of Derek.
- 2005– 1hTV-149.0 (1.9K)TV EpisodeDirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglBurke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglRichard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglEveryone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
- DirectorDan LernerStarsEllen PompeoSandra OhKatherine HeiglMeredith becomes a patient, and Derek and Addison are equally angry at Richard for allowing Mark to join the staff. Meanwhile, Izzie receives a visit from Denny's father, and Burke is plagued by doubt over his ability to return to surgery.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglIzzie fights to save her patient's life, George searches for the son of his patient, and Alex has to contend with the relatives of victims. Meanwhile, Meredith is unconscious underwater, with Derek her only hope.
- DirectorAdam ArkinStarsEllen PompeoSandra OhKatherine HeiglAn unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
- DirectorJoanna KernsStarsEllen PompeoSandra OhKatherine HeiglThe residents and interns squabbling over procedures upsets Dr. Hunt, Erica discovers what happened to the heart she lost, and Derek asks Sloan to break out the McSteamy to distract Yang.
- DirectorEric StoltzStarsEllen PompeoSandra OhKatherine HeiglIzzie wrestles with her ghost, Torres uses a ground-breaking procedure to get her mind off of Hahn, and the interns continue teaching themselves spurred on by a new cohort.
- DirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglSadie manipulates the interns into performing a procedure that goes horribly wrong, Izzie's ghost refuses to leave, and Mark bonds with a girl who's taken responsibility for her sleep-walking father.
- DirectorArlene SanfordStarsEllen PompeoSandra OhKatherine HeiglThe residents make their cases for the solo surgery, Sadie chafes at her restrictions, and Sloan battles his desires.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglDerek has trouble with objectivity concerning his death row patient, Cristina and Meredith continue their feud, Izzie confides her problem to Alex, and the Chief faces what's become of his life's work.
- DirectorJeannot SzwarcStarsEllen PompeoSandra OhKatherine HeiglDerek's mother visits, the death row patient starts angling for death in the hospital, Izzie craves more in her relationships, and Jackson's need for organs becomes critical.
- DirectorAllison Liddi-BrownStarsEllen PompeoSandra OhKatherine HeiglMeredith and Miranda each cross a line, William Dunn regrets his decision and Izzie finally confronts what Denny's appearance means.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglA car crash involving students going to their college graduation takes its toll on the residents in the ER, Derek's wedding gift is uniquely suited for Meredith - even if the oversight is not. Meanwhile, Denny's return has Derek and Bailey searching for the cause, and the results will change the outcome of the day.
- DirectorBill D'EliaStarsEllen PompeoSandra OhKatherine HeiglIzzie is torn over whether to have Derek's proposed brain surgery. A soldier on medical leave asks for a radical operation so he can return to active duty. The Chief tries to lure Bailey back to general surgery with a new toy, and Mark shifts into high gear with major life changes.