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- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe first shift for new surgical interns Meredith, Cristina, Izzie, George, and Alex proves eventful and backbreaking.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglA rape victim is admitted, who managed to hold onto part of her attacker; Izzie has difficulty with a patient who cannot speak English; Meredith becomes concerned about a sick baby.
- DirectorTony GoldwynStarsEllen PompeoSandra OhKatherine HeiglIzzie and Cristina are assigned a close-to-brain-dead John Doe who may be a viable candidate for organ donation, and helpful to George's patient, who needs a new liver. Meanwhile, Meredith and Alex butt heads over a patient of their own.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglAlex uses Izzie's modeling against her, and her last ad causes a patient to reject her care. Meredith finds parallels between a patient and her mother, and Christina must deal with a hospital-savvy patient.
- DirectorJohn David ColesStarsEllen PompeoSandra OhKatherine HeiglMeredith worries she did something wrong during a heart bypass, an error in a past procedure is discovered, putting a staff member's conduct under scrutiny, while a party thrown by Izzie to introduce her boyfriend becomes a fiasco.
- DirectorScott BrazilStarsEllen PompeoSandra OhKatherine HeiglA woman with a massive tumor is admitted, with all the surgeons required to scrub in. In their absence, Meredith is assigned a patient with Parkinson's and, because Alex's pager is not working, Izzie is left in charge of the floor herself.
- DirectorDarnell MartinStarsEllen PompeoSandra OhKatherine HeiglIzzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
- DirectorSarah Pia AndersonStarsEllen PompeoSandra OhKatherine HeiglMeredith wants to learn more about Derek, but he remains cagey. Meanwhile, a supposedly psychic patient proves bothersome, Alex must convince a young girl to agree to a life saving operation, and Cristina is conflicted about her pregnancy.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglGeorge finally gets laid but gets syphilis. It's rampant among staff. Surgeon Webber is losing his sight. He wants Shepherd to operate secretly. A male patient has an ovary. A lifesaving autopsy's performed without consent.
- 2005– 43mTV-148.3 (1.7K)TV EpisodeDirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglMeredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglA family is admitted after being involved in a car crash, but there is more to them than meets the eye. Meanwhile, Bailey and her team deal with a strange case, and relationship woes plague Meredith, Cristina and George.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglMeredith is horrified when her mother is admitted, and everyone is concerned when Cristina collapses in the operating room. Meanwhile, Addison is determined to save a very sick baby.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglCristina is determined to get back to work, and despite not being fully recovered, she manages to crack an odd case. Meanwhile, Addison offers to help Bailey with a complicated surgery, and Alex receives important news.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglA storm rages, causing power outages and jamming the elevator, trapping George and Alex inside with a vulnerable patient. Meanwhile, Meredith and Derek arrange a religious ritual for a young woman, and Cristina deals with an unusual case.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglA train wreck brings in multiple casualties, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his mojo a disheartening experience, and Cristina searches high and low for a missing appendage.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglDerek reluctantly attends marriage counseling with Addison, while Meredith, Izzie and Cristina steal a patient with an unusual problem. Alex helps a young patient gain her independence, and Cristina thinks Bailey knows about her and Burke.
- DirectorLesli Linka GlatterStarsEllen PompeoSandra OhKatherine HeiglFriends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.
- DirectorMichael DinnerStarsEllen PompeoSandra OhKatherine HeiglThanksgiving sends the occupants of Meredith's house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner to which it appears no one is coming.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglMeredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe mother of the quints blames herself. Meanwhile, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina takes care of an inmate desperate to stay at the hospital.
- 2005– 1hTV-148.1 (1.4K)TV EpisodeDirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglChristmas hits Seattle, with Izzie caring for a man who fell from his roof while hanging decorations. Meanwhile, Cristina helps perform a heart transplant on a depressed boy, and George has to contend with the family from Hell.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglIzzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglMeredith must choose between her dog and her roommates. Meanwhile, George deals with an elderly patient who has outstayed her welcome, Bailey's pregnancy has complications, Alex gets his exam results, and Richard has a strike on his hands.
- DirectorDavid PaymerStarsEllen PompeoSandra OhKatherine HeiglThe nurses are striking, and George refuses to cross the picket line. The interns are surprised by Bailey's seemingly immature replacement, Izzie connects with a pregnant girl, and an elderly woman's plight pushes Meredith to the limit.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe lives of everyone in the OR are threatened when a patient enters with a bomb inside him, and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglWhile the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglDerek and Addison are shaken by the arrival of a figure from their past. Meanwhile, Burke learns Cristina's secret, Izzie deals with a very unusual case, Meredith delves into her family's dirty laundry, and George pours his heart out.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglMeredith and George face the consequences of their actions, Izzie gets closer to Denny, who has been readmitted, and Addison asks for Bailey's help with an embarrassing ailment.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglCristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.
- DirectorTricia BrockStarsEllen PompeoSandra OhKatherine HeiglSuperstition strikes, with the interns convinced a series of deaths will occur. A complication from the LVAD surgery puts Denny in the OR, Cristina plans to make George move out, and Richard's old AA sponsor is admitted for treatment.
- DirectorSeith MannStarsEllen PompeoSandra OhKatherine HeiglCristina is desperate for George to move out of the apartment, while Izzie is jealous of Callie's relationship with him. Meanwhile, Cristina and Richard are rivals in a surgery seminar, and Meredith discovers a secret about her father.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglMeredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
- DirectorTony GoldwynStarsEllen PompeoSandra OhKatherine HeiglThe victims of a serious car accident are admitted, with every surgeon required to help. Meanwhile, Callie's forwardness grates on Izzie, Addison makes Alex suffer, and Derek takes his frustration out on Meredith.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe victims of a workplace shooting are admitted. Izzie puts her job on the line to ensure Denny gets a new heart, Callie makes an effort with Meredith, and Addison is suspicious of Derek.
- 2005– 1hTV-149.0 (1.9K)TV EpisodeDirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglBurke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglRichard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglEveryone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
- DirectorNeema BarnetteStarsLauren GrahamAlexis BledelMelissa McCarthyRory tries dating in college. Lorelai is still adjusting to an empty house.
- DirectorAlex GravesStarsStockard ChanningDulé HillAllison JanneyBack in Washington briefly, Josh visits the White House and is surprised to discover that as a campaign manager he is no longer part of the inner circle in an administration that wants to remain neutral in the Democratic primary. Toby is the focus of some concern after being more withdrawn than usual and also because he is nursing a cut on his face that he doesn't want to talk about. Charlie tells Kate that a guy at his gym has been asking about her, but she's unsure if she's ready to date again. A multi-state water rights fight pitches C.J. against lobbyist Cliff Calley, who proves to be both infuriating and intriguing. Josh and Donna are both suspicious when far-left Senator Rafferty joins the race, obviously as a spoiler candidate.
- DirectorRandy ZiskStarsKerry WashingtonColumbus ShortDarby StanchfieldOlivia is tasked with finding a woman for a Goburnatorial candidate who is rumored to be gay by his family. Fitz wants to rescue the hostages but he has to find out who the leak is. Cyrus and Mellie who feel as if Fitz is shutting them out tries to show the other up. And Olivia is seeing Jake socially. and it turns out that Jake was tasked with keeping an eye on Olivia by Fitz. David thinks someone is following him so he turns to Olivia. They later learn that he is being followed by someone who knows the girl whom he is being framed for killing. And she claims to know who really killed her and she could be next.
- DirectorGary HalvorsonStarsJennifer AnistonCourteney CoxLisa KudrowPhoebe and Joey purposely set Ross and Rachel up on bad dates in the hopes they'll get back together. Monica and Chandler babysit Emma.
- DirectorBarbara BrownStarsChris ColferDarren CrissDot-Marie JonesThe final of the competition between Warblers, Vocal Adrenaline and New Directions is here. Meanwhile, Kurt and Blaine are trapped in an elevator with a Sue-Saw-Marionette.