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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- Chief of experimental medicine at prestigious hospital uses unorthodox healing methods on critically ill patients. Skilled healer mentors young doctors while treating patients.
- In the near future, a law firm handles difficult cases that reflect the time.
- Del Canyon reluctantly returns to his small hometown to run his family's apothecary, the only source for medical attention for hundreds of miles. The series will follow his emergence as the town healer while he grapples between his desire to distance himself from a painful past and his inability to turn his back on a community struggling to find its place in contemporary America.
- Marty takes on the case of a woman fighting for possession of her dead husband's computerized likeness. Lee May and Darwin find themselves defending a son whose mother is sabotaging his dating life in order not to lose him.
- The firm deals with a case where a mentally dysfunctional man is cured by a process that may ultimately kill him. At the same time they deal with a case that may redefine what a family actually is.
- The firm takes on the national baseball league after a drafted player is banned because he has potential advantages over other players. They also have to combat a lawsuit for work place place harassment brought against one of the associates.
- A case comes up in which genetically tailored children are prone to a high incident of homosexuality. And a woman cyber hijacks the personality of her ex boyfriend because she was lonely.
- The firm take on a case where a man is caught smuggling his own cells back into the country to attempt to clone himself for a life saving operation. An 80's Boy band are in a feud after one of them refuses the plastic surgery to make him look young again.
- The firm agree to handle a case where a woman is claiming she was raped even though she acknowledges the rapist was 20 miles away. A child star brings action to attempt to divorce his parents.
- A teenage girl takes her parents to court because of a tracer system they use that follows every move she makes night and day. A man is in trouble over pre wedding plans when a mate finder program continues to send him suggestions about possible dates.
- A cleaning lady Gideon has known for years comes to the hospital with leukemia.
- A man whom Gideon once treated for cancer comes back to the hospital with a fever and a son who has a chip on his shoulder. Meanwhile, Boies is unable to determine what caused a 35-year-old woman to have a stroke.
- The flirtatious daughter of the hospital's psychiatry chief commits suicide - after she leaves a note accusing Cherry of sexual misconduct. Also, Boies grows more anxious as preparations for the Porter malpractice trial heat up.
- A rich woman with a blood disease picks on the staff, including Gideon and Cabranes. In the meantime, the residents set out to fulfill a dying patient's last wish to be mummified.
- Two patients are in desperate need of a liver transplant when a brain-dead accident victim shows up at the hospital, so Brucie must convince her parents to donate her organs. In the meantime,
- Ellenor Frutt is brought to Metropolitan General after collapsing and tells Ben that her baby comes first if anything happens to her.
- Gideon has developed a drug that could revolutionize treatment for melanoma. The drug is given approval for trials and he offers it to one of his patients before learning that trial subjects must be chosen by a lottery.
- Gideon gets severe heartburn and faints in an exam room. His EKG results are "ambiguous," but he refuses to believe there is something wrong with him, even as Cabranes says it could be a heart attack.
- Staffers look for bacteria that are causing infections in patients who have no connection other than the fact that they're sick.
- During the holidays, Gideon attempts to treat an anemic astronomer who disagrees with the hematology chief. Also, Cabranes volunteers to sing for the hospital's "holiday extravaganza", but Stiles doubts his talent.
- A frequent drug-test volunteer to whom Ollie has gotten close is diagnosed with leukemia. He responds to an experimental treatment, only to get arrested for robbery, but the bright side is that he can't be treated in jail.
- A deaf 14-year-old girl asks for a cochlear implant, but her parents, who are also deaf, are against it. A lawyer for the hospital asks Gideon out and a patient Sid pronounced dead turns out to be alive, but in a vegetative state.
- Boies' father comes to the hospital as a visitor, then ends up as a patient after coughing incessantly in front of Sid. In the meantime, Gideon wonders how a teenage hemophiliac has developed a resistance to the clotting factor.