When Lucy gets stabbed by the knife the blade is has a vertical orientation, but later when she is stapling her incision closed, her incision is horizontal and not vertical.
Janey is watching the city as the bomb hits, the flash of light from the explosion would have caused instant blindness.
When Lucy leaves the vault she sees several bodies apparently petrified like the figures that tourists can see from Pompei. The figures at Pompei were artificially crested by pouring cement into voids created when the bodies decomposed. There is not a process which would petrify a body like that.
The story starts in what looks like the late 1950's, and then jumps "219" years later. However, the dates on the wedding dress state year's around 2280, which is more 319 years later. - According to the game series that this show is based on the bombs were dropped in October of 2077. 219 years later would be near 2280.