The "procedure" Dr. Lydgate prepares to perform on Alice is mostly likely a removal of parts of the cerebral cortex. This form of psychosurgery was first performed by Gottlieb Burckhardt in December, 1881.
This episode takes its name from the first chapter of the novel Alice's Adventures in Wonderland.
The title card has no special feature, unlike the title cards for the rest of the series.
The title of this episode was announced by Adam Horowitz via his Twitter account on August 8, 2013.
This is Keith David's second time voicing a talking cat character. His first was in the 2009 movie named Coraline, which many see as an Alice in Wonderland themed movie.