Despite being naked throughout the film, Joe Lo Truglio wore a prosthetic penis. Most of the cast ran up to him and touched it as a joke after showing up on set.
Jennifer Aniston reconnected with her husband Justin Theroux on the set of this film. They had originally met in 2008 after being introduced by Robert Downey Jr.. As of June 2019, they are legally separated.
The trailer has a clip of Paul Rudd walking into his room to find Jennifer Aniston lying on the bed with two other women. Rudd asks "What happened?" to which Aniston replies "You just missed it. It was so beautiful." This clip is not in the movie.
This was the last film to use the late 1990s Universal logo.
David Wain: [Jim Stansel] The name "Jim Stansel" that appears on the business card is in every David Wain movie.