Peter Krause would later publicly voice his displeasure that the tone of the show was changed during the editing process, and he vowed to never work at ABC again.
Sheryl Lee (Andrea) and Chloë Grace Moretz (Kiki) subsequently played mother and daughter in Texas Killing Fields (2011).
After ABC canceled the show at the end of 2008, the last four episodes of the 2nd season remained unaired until Spanish TV-channel Antena 3 aired them in March 2009. This means, the last episodes of the show had their world premiere on Spanish television and were not aired in the US until the Summer of 2009.
Several actors are replaced after the pilot. E.g. Elle Fanning (as Kiki George) is replaced by Chloë Grace Moretz from episode two, and Brooke Smith (as Andrea Smithson) is replaced by Sheryl Lee, when the character reappears in episode 7.
Sheryl Lee, whose character Andrea battles cancer, participated in Munchkin's Project Pink to raise money for breast cancer research while starring on the show. She had previously portrayed a woman battling cancer on One Tree Hill (2003).