Isabella Parigi's singing voice is by Haylie Duff, Hilary Duff's sister, dubbing over her sister's voice.
Despite serving as the canonical ending of the Lizzie McGuire (2001) series, with the main characters graduating middle school, new episodes of the series continued to air for almost a year after the release of the film.
Aside from a sequel to the film, Disney planned a second show for ABC that would've focused on Lizzie's adventures in high school. However, just a month after the film was released, negotiations fell through, as confirmed by Hilary's mother, Susan Duff, through Entertainment Weekly. "Disney thought they'd be able to bully us into accepting whatever offer they wanted to make, and they couldn't. We walked away from a sequel. They walked away from a franchise." Duff was also supposed to get a $500,000 bonus if the movie made $50 million.
Mr. Escobar jokes that the class president contracted the Ebola virus. The first Ebola outbreak in America occurred 11 years after the release of this film.
Both Lizzie (Elizabeth) and Isabella are European translations of the Hebrew name Elisheva, which means "God is my oath."