John Freeman begins the series by interviewing lawyer Lord Norman Birkett. Some of the heavy topics under discussion include whether he had defended someone he believed was guilty of murder, and the emotions of delivering a death sentence.
Philosopher Bertrand Russell is the second guest on the series, beginning the interview by reading from a fictitious obituary he'd written for himself. Among the topics discussed are guilt, sex, money, childhood, prison and loss of faith.
John Freeman interviews the first of just two female guests in the series - poet Dame Edith Sitwell. The Dame discusses her unhappy childhood, her working relationship with Dylan Thomas, and her unexpected diversion into Hollywood.
Adlai Stevenson relives his early life in journalism and law, and discusses losing two Presidential elections to Dwight Eisenhower. Among his other reflections are how others see him, and how he sees himself.
A cigar-puffing John Huston discusses his directing career, his desire to make films under the United Nations, his relationship with his father and fighting with Errol Flynn.
John Freeman interviews Carl Jung at his Zürich home, asking the psychologist questions about consciousness, his friendship with Freud, his thoughts on death, and his own self-analysis.
Racing driver Stirling Moss is called upon to ponder his career. Customary for the series, the questions go deeper than usual interviews: Does he think about mortality? Does he feel close to God? What about the breakdown of his marriage?
Evelyn Waugh takes part in the series due to what he claims is "poverty", and that "everyone thinks ill of the BBC". Among the topics under discussion are religion, truth in fiction, and Waugh's own periods of mental illness.