Spencer Tracy initially was not pleased with the studio's choice of director, hoping to have George Cukor or Vincente Minnelli assigned the position.
Fay Hendry, the mother of Sonya Hendry, a young girl who appeared in the film, was awarded nearly $30,000 for injuries sustained when the girl was struck by a falling reflector at the site of location filming.
The poem that Cass Timberlane recites at the picnic with Virginia is "First Fig" by Edna St. Vincent Millay.
According to an April 1945 article in The Hollywood Reporter, MGM reportedly paid $150,000 (nearly $2.5M in 2022) for the film rights to Sinclair Lewis' novel.