While "Pals in the Saddle" is considered the first Republic Three Mesquiteer film, It is not the first. The first was made at RKO in 1935 and named "Powdersmoke Range" (1935). The stars were John Wayne's boyhood hero Harry Carey as Tucson Smith. another former John Ford star, Hoot Gibson as Stony Brooke and Big Boy Williams as Lullaby Joslin. The supporting cast included Bob Steele and Tom Tyler.
The music used when the wanted poster is being nailed up was reused in "The Lone Ranger" TV show.