Throughout filming, RKO executives complained that the film was destined for commercial failure. They asked Howard Hawks to insert more romance and less slapstick and told him to take away Cary Grant's glasses, but he ignored them.
Katharine Hepburn had never done any comedy before, and was coached by Howard Hawks and several veteran vaudevillians he employed solely for that purpose. As a former vaudevillian, Cary Grant was already well versed in comedy.
The scene in which Susan's dress is ripped was inspired by something that happened to Cary Grant. He was at the Roxy Theater one night and his pants zipper was down when it caught on the back of a woman's dress. Grant impulsively followed her. When he told this story to Howard Hawks, Hawks loved it and put it into the film.
Christopher Reeve based his performance as Clark Kent in Superman (1978) and its three sequels on Cary Grant's character David Huxley from this film.
Katharine Hepburn had one very close call with the leopard. She was wearing a skirt that was lined with little metal pieces to make the skirt swing prettily. When Hepburn turned around abruptly, the leopard made a lunge for her back. Only the intervention of the trainer's whip saved Hepburn. The leopard was not allowed to roam around freely after that, and Hepburn was more careful around it from then on.