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- DirectorDavid VelozStarsBen StillerMaria BelloJay PaulsonA comedy writer struggles to overcome his addiction to heroin while putting his professional and personal life in danger.
- DirectorRobert ZemeckisStarsDenzel WashingtonNadine VelazquezDon CheadleTroubling questions arise after airline pilot Whip Whitaker makes a miracle landing after a mid-air catastrophe.
- DirectorSam Taylor-JohnsonStarsAaron Taylor-JohnsonBilly Bob ThorntonOdessa YoungA drug-dependent young man faces his past and his inner demons after he is interned in an institution for the addicted.
- DirectorGlenn Gordon CaronStarsMichael KeatonKathy BakerMorgan FreemanA hustling drug addict checks himself into rehabilitation to escape trouble with the law and realizes that it's exactly what he needs.
- DirectorGus Van SantStarsJoaquin PhoenixJonah HillRooney MaraOn the rocky path to sobriety after a life-changing accident, John Callahan discovers the healing power of art, willing his injured hands into drawing hilarious, often controversial cartoons, which bring him a new lease on life.
- DirectorBetty ThomasStarsSandra BullockViggo MortensenDominic WestA big-city newspaper columnist is forced to enter a drug and alcohol rehab center after ruining her sister's wedding and crashing a stolen limousine.
- DirectorJonathan DemmeStarsAnne HathawayRosemarie DeWittDebra WingerA young woman who has been in and out of rehab for the past ten years returns home for the weekend for her sister's wedding.
- DirectorBarbet SchroederStarsMickey RourkeFaye DunawayAlice KrigeBased on the life of successful poet Charles Bukowski and his exploits in Hollywood during the 60s, 70s, and 80s.
- DirectorFelix van GroeningenStarsSteve CarellMaura TierneyJack Dylan GrazerBased on the best-selling pair of memoirs from father and son David and Nic Sheff, Beautiful Boy chronicles the heartbreaking and inspiring experience of survival, relapse and recovery in a family coping with addiction over many years.
- DirectorPeter HedgesStarsJulia RobertsLucas HedgesCourtney B. VanceA drug addicted teenage boy shows up unexpectedly at his family's home on Christmas Eve.
- DirectorLuis MandokiStarsMeg RyanAndy GarciaEllen BurstynThe seemingly perfect relationship between a man and his wife is tested as a result of her alcoholism.
- DirectorDanny BoyleStarsEwan McGregorEwen BremnerJonny Lee MillerRenton, deeply immersed in the Edinburgh drug scene, tries to clean up and get out despite the allure of drugs and the influence of friends.
- DirectorDanny BoyleStarsEwan McGregorEwen BremnerJonny Lee MillerAfter 20 years abroad, Mark Renton returns to Scotland and reunites with his old friends Sick Boy, Spud, and Begbie.
- DirectorDarren AronofskyStarsEllen BurstynJared LetoJennifer ConnellyThe drug-induced utopias of four Coney Island people are shattered when their addictions run deep..
- DirectorBilly WilderStarsRay MillandJane WymanPhillip TerryThe desperate life of a chronic alcoholic is followed through a four-day drinking bout.
- DirectorPaul Thomas AndersonStarsMark WahlbergJulianne MooreBurt ReynoldsBack when sex was safe, pleasure was a business and business was booming, an idealistic porn producer aspires to elevate his craft to an art when he discovers a hot young talent.
- DirectorSteven SoderberghStarsMichael DouglasBenicio Del ToroCatherine Zeta-JonesA conservative judge is appointed by the President to spearhead America's escalating war against drugs, only to discover that his teenage daughter is a crack addict. Two DEA agents protect an informant. A jailed drug baron's wife attempts to carry on the family business.
- DirectorTed DemmeStarsJohnny DeppPenélope CruzFranka PotenteThe story of how George Jung, along with the Medellín Cartel headed by Pablo Escobar, established the American cocaine market in the 1970s in the United States.
- DirectorMike FiggisStarsNicolas CageElisabeth ShueJulian SandsBen Sanderson, a Hollywood screenwriter who lost everything because of his alcoholism, arrives in Las Vegas to drink himself to death. There, he meets and forms an uneasy friendship and non-interference pact with prostitute Sera.
- DirectorBruce RobinsonStarsRichard E. GrantPaul McGannRichard GriffithsIn 1969, two substance-abusing, unemployed actors retreat to the countryside for a holiday that proves disastrous.
- DirectorJames PonsoldtStarsMary Elizabeth WinsteadAaron PaulNick OffermanA married couple whose bond is built on a mutual love of alcohol gets their relationship put to the test when the wife decides to get sober.
- DirectorAlex CoxStarsGary OldmanChloe WebbDavid HaymanThe relationship between Sid Vicious, bassist for British punk group Sex Pistols, and his girlfriend Nancy Spungen is portrayed.
- DirectorMike NicholsStarsElizabeth TaylorRichard BurtonGeorge SegalA bitter, aging couple, with the help of alcohol, use their young houseguests to fuel anguish and emotional pain towards each other over the course of a distressing night.
- DirectorTaylor HackfordStarsJamie FoxxRegina KingKerry WashingtonThe story of the life and career of the legendary rhythm and blues musician Ray Charles, from his humble beginnings in the South, where he went blind at age seven, to his meteoric rise to stardom during the 1950s and 1960s.
- DirectorGus Van SantStarsMatt DillonKelly LynchJames Le GrosA pharmacy-robbing dope fiend and his crew pop pills and evade the law.