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- DirectorHugh LaurieStarsHugh LaurieOmar EppsRobert Sean Leonard6 y.o. Emily gets a nose bleed and faints. Her dad gets her to the hospital, her mom's a doctor. Wilson has cancer, House is there for him.
- DirectorJames HaymanStarsHugh LaurieLisa EdelsteinOmar EppsThe team tries to treat a patient who keeps lying to them, and Foreman exerts some independence.
- DirectorMiguel SapochnikStarsHugh LaurieOmar EppsRobert Sean LeonardHouse is more interested in a case that Foreman brings of a 4 year old dead boy than the 14 year old live girl. The team takes care of her while he sees the boy's dad and corpse.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse takes on a case where the patient has unexplained blackouts, and his daughter may hold the key to the diagnosis. Meanwhile, Cuddy prepares for her new arrival until there are complications with the birth mother.
- DirectorSteven DePaulStarsFreddie HighmoreNicholas GonzalezAntonia ThomasShaun recalls his own past to help an intellectually disabled teenager, while Claire is put between an injured teenage rock climber and her worried parents. Meanwhile, Glassman's post-op hallucinations force him to confront a personal tragedy.
- DirectorBabu Subramaniam 'T.R.'StarsNoah WyleLaura InnesMekhi PhiferDr. Romano seizes control of the ER and manages to offend everyone. Dr. Kovac asks Dr. Corday's help in the quest to bring a sickly Croatian boy to the U.S. for medical treatment.
- DirectorJoanna KernsStarsFreddie HighmoreNicholas GonzalezAntonia ThomasShaun learns to drive, Dr. Melendez and Dr. Lim are about to see who becomes the head of Surgery, Shaun tries his hand on being empathetic and most important, shocker for Dr. Reznick and Dr.Claire.
- DirectorLarry TengStarsFreddie HighmoreNicholas GonzalezAntonia ThomasAt St. Bonaventure Hospital, Dr. Shaun Murphy encounters a young patient who looks eerily similar to his deceased brother, Steve. After discovering that the patient's parents have hidden his diagnosis from him, Shaun struggles to understand why the patient doesn't deserve to hear the truth about his own health. Meanwhile, the team can't figure out what keeps triggering their patients' increasingly severe allergic reactions and races to find the cause before another patient dies.
- DirectorJohn DahlStarsFreddie HighmoreNicholas GonzalezAntonia ThomasClaire is learning to communicate with Shaun as they race to the hospital with a donated organ and perform surgery on the organ while on a freeway ramp. But the recipient winds up losing his entitlement to the kidney.
- DirectorMike ListoStarsFreddie HighmoreNicholas GonzalezAntonia ThomasWhen prejudices about his autism force Shaun to sit on the sidelines at St. Bonaventure, a colleague doesn't hesitate to claim credit for his ideas. Meanwhile, Dr. Murphy is relentless in saving a young girl's life.
- DirectorMina ShumStarsFreddie HighmoreFiona GubelmannWill Yun LeeA personal connection threatens Shaun's objectivity.
- DirectorRegina KingStarsFreddie HighmoreNicholas GonzalezAntonia ThomasA teenage patient hopes the surgical team can free her from a life of confinement at home; a young patient's perfectly matched organ donor is causing a moral dilemma for the parents and the patient.
- DirectorDavid StraitonStarsFreddie HighmoreNicholas GonzalezAntonia ThomasDr. Murphy, Dr. Reznik and Dr. Kim treat a woman who has autism and a delicate brain condition; Lea and Shaun work to figure out their friendship and roommate status.
- DirectorMike ListoStarsFreddie HighmoreNicholas GonzalezAntonia ThomasThe team needs to quickly discover the truth behind a young college student's unexplained injuries before his condition worsens; after losing a prized possession, Shaun's distraction during a surgical procedure may risk more than his job.
- DirectorDaniel AttiasStarsColin FarrellRachel McAdamsTaylor KitschAs Ani, Paul, and Ray get closer to finding out the truth about Caspere, circumstances become more dangerous for them all and everyone around them. Frank deals with an inside betrayal, learns important information, and plans his next move.
- DirectorMiguel SapochnikStarsColin FarrellRachel McAdamsTaylor KitschDesperate to locate a missing woman with intel about Caspere, Frank meets with Mexican drug dealers; Ani infiltrates an exclusive inner circle, with Ray and Paul keeping close tabs.
- DirectorCharles McDougallStarsAmy PoehlerRashida JonesAziz AnsariRon's Pawnee Rangers and Leslie's competing scout group, the Pawnee Goddesses, share a weekend in the wilderness, Ben joins Tom and Donna on "Treat Yo Self Day," and Chris takes an interest in Jerry's daughter.
- DirectorMike ListoStarsFreddie HighmoreAntonia ThomasFiona GubelmannDuring part one of the two-part season finale, the St. Bonaventure team travels to Guatemala on a surgical mission to help patients at a rural hospital. Once there, the team faces a small community that is in desperate need of their help but are assigned the daunting task of identifying who they can help most. And while Shaun seems to be thriving in Guatemala, Lea is still struggling with the loss of her baby.
- DirectorMykelti WilliamsonStarsNick GehlfussYaya DaCostaTorrey DeVittoDr. Charles and April team up to take on a mysterious patient in the ED. Dr. Halstead is forced to make a life-or-death decision for one of his trial patients. Dr. Marcel is confronted by his past when a former acquaintance is brought into the ED.
- DirectorMykelti WilliamsonStarsJason BegheJesse Lee SofferTracy SpiridakosAfter injuring herself while pursuing a suspect, Burgess receives a shocking diagnosis. A homicide case turns into a missing persons case, with a sinister twist. Voight has to decide between justice and the letter of the law.
- DirectorLeslie LibmanStarsJesse SpencerTaylor KinneyKara KillmerGorsch takes over Boden's morning meeting at Firehouse 51 and goes out on calls in his place; Brett and Foster respond to a call about a Halloween prank getting deadly serious.
- DirectorLeslie LibmanStarsJesse SpencerTaylor KinneyMonica RaymundBoden takes a big step in the pursuit of a major career decision. Kidd becomes increasingly distrustful of Renee's motives with Severide. Herrmann has trouble bouncing back after a tragedy.
- DirectorNicole RubioStarsJason BegheJon SedaJesse Lee SofferAntonio crosses a line that puts the entire team at risk.