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- CreatorMichael CrichtonStarsAnthony EdwardsGeorge ClooneyJulianna MarguliesThe doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- CreatorShonda RhimesMichelle LirtzmanStarsEllen PompeoChandra WilsonJames Pickens Jr.A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- CreatorGreg BerlantiStarsTreat WilliamsGregory SmithEmily VanCampA widowed brain surgeon from Manhattan moves his two children to the small mountain town of Everwood, Colorado.
- CreatorKevin WilliamsonStarsJames Van Der BeekKatie HolmesMichelle WilliamsTwo childhood best friends, Dawson and Joey, go through different stages of adolescence together. Their friendship is later tested when they both start a relationship with different people.
- CreatorJ.J. AbramsMatt ReevesStarsKeri RussellScott SpeedmanScott FoleyA young girl, fresh out of high school, follows her high school crush to college to be near him.
- CreatorAmy BrennemanBill D'EliaBarbara HallStarsAmy BrennemanTyne DalyKarle WarrenA family drama focused on three generations of women living together in Hartford, Connecticut.
- CreatorJohn MasiusStarsMelina KanakaredesMike FarrellPaula CaleA cosmetic surgeon returns to her hometown to care for her Father and siblings.
- CreatorDarren StarStarsHeather LocklearAndrew ShueCourtney Thorne-SmithClassic serial drama around a group of friends living in Melrose Place, California.
- CreatorTodd SlavkinDarren SwimmerDarren StarStarsKatie CassidyStephany JacobsenJessica LucasA new generation of young professionals living at the infamous Melrose complex deal with obtaining their own personal goals, drives, and desires, both amongst themselves and others.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorChuck LorreDottie Dartland ZicklinStarsJenna ElfmanThomas GibsonJoel MurrayA free-spirited yoga instructor finds true love in a conservative lawyer and they get married on the first date. Though they are polar opposites, he fulfills her need of stability and she fulfills his need of optimism.
- CreatorLarry DavidJerry SeinfeldStarsJerry SeinfeldJulia Louis-DreyfusMichael RichardsThe continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorLinwood BoomerMichael GloubermanGary MurphyStarsFrankie MunizBryan CranstonJustin BerfieldA gifted young teen tries to survive life with his dimwitted, dysfunctional family.
- CreatorDavid LittMichael J. WeithornStarsKevin JamesLeah ReminiJerry StillerDeliveryman Doug Heffernan has a good life: He has a pretty wife (Carrie), a big television, and friends with which to watch it. Then Carrie's goofy, annoying father Arthur moves in with them.
- CreatorTracy NewmanJonathan StarkStarsJim BelushiCourtney Thorne-SmithLarry Joe CampbellA television show centered around a macho everyman, his loving wife, and their three precocious children.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorDon ReoDamon WayansStarsDamon WayansTisha CampbellGeorge Gore IIMichael Kyle longs for a traditional life, but his day-trader wife Janet, gangsta rap-worshipping son Michael Jr., and brooding daughters Claire and Kady make his dream just that ... a dream.
- CreatorPhil RosenthalStarsRay RomanoPatricia HeatonBrad GarrettThe comical everyday life of sports columnist Ray Barone and his dysfunctional family.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoAspiring film actress Penny Teller moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- CreatorDanny JacobsonKenny SchwartzRick WienerStarsTraylor HowardRyan ReynoldsRichard RuccoloThree twenty-somethings share a Boston apartment and hang around (and work) at a pizza place.
- CreatorSeth MacFarlaneDavid ZuckermanStarsAlex BorsteinSeth MacFarlaneSeth GreenIn a wacky Rhode Island town, a dysfunctional family strives to cope with everyday life as they are thrown from one crazy scenario to another.
- CreatorJ.J. AbramsJeffrey LieberDamon LindelofStarsJorge GarciaJosh HollowayYunjin KimThe survivors of a plane crash are forced to work together in order to survive on a seemingly deserted tropical island.